Withdrawal from Oxycodone

Reducing your oxycodone dose or suddenly stopping the drug can trigger vomiting, heavy sweating, diarrhea, aching muscles and other flu-like withdrawal symptoms. Oxycodone withdrawal is so difficult, that it’s often an obstacle to recovery from addiction. Detox and treatment can ease the process.
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If you use oxycodone for more than two weeks, you’re likely to become physically dependent on the drug.

Dependence means your body has adapted to the presence of oxycodone in your system and needs it to function normally. When you’re dependent on oxycodone, you’ll experience uncomfortable withdrawal system if you cut back on your dose, or abruptly stop taking the drug.

Oxycodone withdrawal can range from mild to severe depending on how much you’ve been taking and how long you’ve been taking it.

Withdrawal symptoms are often so excruciating that people are unable to stop using the drug without professional help. The withdrawal phenomenon, in fact,is one of the key contributors to oxycodone addiction.

Oxycodone Withdrawal Symptoms

Withdrawal symptoms may vary from person to person, but most people experience an array of flu-like symptoms, including nausea, body aches, fever and stomach upset.

Oxycodone withdrawal symptoms are the same as withdrawal symptoms from other prescription opioids, such as morphine, codeine and hydrocodone.

Symptoms of oxycodone withdrawal include:

  • Restlessness
  • Watery eyes and runny nose
  • Yawning
  • Sweating
  • Chills
  • Body aches
  • Weakness
  • Irritability and anxiety
  • Depression
  • Insomnia or difficulty falling asleep
  • Abdominal cramps
  • Nausea and vomiting
  • Diarrhea
  • Loss of appetite
  • Increased heart rate
  • High blood pressure
  • Rapid breathing

Other symptoms of oxycodone withdrawal include hot and cold flashes, goosebumps and twitching. Intense cravings for oxycodone are common. In severe cases of withdrawal, a person may develop dehydration, elevated blood sugar and low blood pressure. They may lie in a curled-up, fetal position.

People who take higher doses of oxycodone and more potent formulations of the drug, such as the extended-release version, OxyContin, usually develop more severe withdrawal symptoms. The longer a person has been using the drug, the worse their withdrawal symptoms are likely to be.

Matt Ganem, a Boston man who developed an OxyContin addiction when he was just 16, told the health and science publication STAT that withdrawing from the drug was pure agony. In a video interview, Ganem recalled the drenching sweats, violent diarrhea, severe anxiety and other symptoms he experienced.

Unable to cope, he eventually turned to heroin. “I was dope sick off of Oxys, curled up like a baby and I couldn’t afford another pill, and someone brought a bag of heroin to me,” Ganem said. “At that point, it didn’t matter to me. I was so sick, I just didn’t want to be sick.”

Oxycodone Withdrawal Timeline

The onset of oxycodone withdrawal can vary, but typically begins around the time a person would have taken their next dose of the drug.

With a short-acting type of oxycodone, such as Percocet, withdrawal symptoms usually start approximately six to eight hours after the previous dose. Symptoms peak in 48 to 72 hours and usually last five to seven days.

Withdrawal from extended-release forms of oxycodone, such as OxyContin, may not develop for at least 12 hours and can last for upwards of one to two weeks.

While the acute physical symptoms of oxycodone withdrawal usually dissipate in days to weeks, psychological effects such as depression, irritability and trouble thinking can linger for weeks or months.

These prolonged symptoms are known as post-acute withdrawal syndrome (PAWS). Up to 90 percent of those recovering from an opioid addiction have some degree of PAWS.

Treating Oxycodone Withdrawal

If you’ve been taking oxycodone continuously for more than two weeks, it’s unadvisable to stop the drug cold turkey.

Opioid Tapering

If you’re under the care of a physician, your doctor may try to wean you off the drug gradually to reduce withdrawal symptoms. This usually takes several days and involves taking a slightly smaller dose of oxycodone every few days.

A case report in the 2012 journal of Pain Therapy describes a 44-year-old woman who was successfully weaned off OxyContin by tapering her dose over a 10-day period and taking Ondansetron, a prescription anti-nausea medication.

Oxycodone Detox

If you are not under the care of a physician, you may want to consider seeking professional drug treatment. Detox centers can manage oxycodone withdrawal symptoms with medications and provide monitoring to insure your safety and comfort.

The U.S. Food and Drug Administration has approved two drugs — methadone and buprenorphine — for the treatment of opioid withdrawal symptoms. Other prescription drugs, including the sedative Clonidine, are also commonly used to manage oxycodone withdrawal. Over-the-counter medications are used frequently to relieve symptoms such as diarrhea and body aches.

While cravings for oxycodone persist for months or years after withdrawal and detox, opioid treatment can lessen the risk of relapse and help you battle the disease of addiction.

Most opioid rehab programs treat oxycodone addiction through a combination of behavioral therapy, individual and family counseling and peer support. Medications such as naltrexone and buprenorphine are often used in combination with counseling and therapy to help people maintain their sobriety.

Treatment for oxycodone addiction is available as both an inpatient and outpatient basis, depending on your needs.

Medical Disclaimer: DrugRehab.com aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.

Amy Keller, RN, BSN
Content Writer, DrugRehab.com
As a former journalist and a registered nurse, Amy draws on her clinical experience, compassion and storytelling skills to provide insight into the disease of addiction and treatment options. Amy has completed the American Psychiatric Nurses Association’s course on Effective Treatments for Opioid Use Disorder and continuing education on Screening, Brief Intervention and Referral to Treatment (SBIRT). Amy is an advocate for patient- and family-centered care. She previously participated in Moffitt Cancer Center’s patient and family advisory program and was a speaker at the Institute of Patient-and Family-Centered Care’s 2015 national conference.
Kim Borwick, MA
Editor, DrugRehab.com

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